MolNFT v1 · #184374 · protein
Mechanosensitive channel mscs solubilized with lmng in closed conformation with added lipid
7OO8 · Mechanosensitive channel of small conductance (mscs): “Mechanosensitive channel mscs solubilized with lmng in closed conformation with added lipid”. Electron microscopy, 20 pockets (best druggability 0.74). MolNFT v1 #184374 on…
- PDB
- 7OO8
- Type
- protein
- Length
- 1,827 residues
- Chains
- 7
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Mechanosensitive channel of small conductance (mscs)
- UniProt
- B6I756
- Pockets
- 20 · best druggability 0.74
Structure
electron microscopy · 1 distinct chain · 53% helix, 23% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E, F, G | Mechanosensitive channel of small conductance (mscs) | protein | 261 | 53% helix, 23% strand | B6I756 |
Pockets
20 pockets found on a 1 Å grid, 16 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 325 | 0.74 | 0.84 | 26 | empty |
| 2 | 1020 | 0.70 | 0.74 | 52 | empty |
| 3 | 53 | 0.61 | 0.92 | 15 | empty |
| 4 | 502 | 0.61 | 0.74 | 58 | empty |
| 5 | 409 | 0.58 | 0.74 | 43 | empty |
Interfaces
14 interfaces between chains.
- D–E · 2785 Ų buried · 27 hydrogen bonds · protein-protein
- F–G · 2771 Ų buried · 26 hydrogen bonds · protein-protein
- B–C · 2770 Ų buried · 27 hydrogen bonds · protein-protein
- E–F · 2770 Ų buried · 27 hydrogen bonds · protein-protein
- C–D · 2768 Ų buried · 25 hydrogen bonds · protein-protein
Compared structures
- 7OO8 · Mechanosensitive channel MscS solubilized with LMNG in closed conformation with added… · the same entry in another collection · chain E against E, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt B6I756
- Elsewhere: RCSB PDB 7OO8 · PDBe 7OO8 · UniProt B6I756
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.