MolNFT v1 · #184303 · protein
Bacillus subtilis complex structure 1 of diadenylate cyclase cdaa cytoplasmic domain (cdaacd) and the phosphoglucomutase glmm short variant (GLMMF369)
7OLH · Phosphoglucosamine mutase: “Bacillus subtilis complex structure 1 of diadenylate cyclase cdaa cytoplasmic domain (cdaacd) and the…”. X-ray diffraction, 20 pockets (best druggability 0.80). MolNFT v1 #184303 on GenesisL1: 3D…
- PDB
- 7OLH
- Type
- protein
- Length
- 3,076 residues
- Chains
- 12
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Phosphoglucosamine mutase; Cyclic di-AMP synthase cdaa
- EC
- 5.4.2.10, 2.7.7.85
- UniProt
- O34824, Q45589
- Pockets
- 20 · best druggability 0.80
Structure
x-ray diffraction · 7 distinct chains · 37% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C | Phosphoglucosamine mutase (EC 5.4.2.10) | protein | 368 | 38% helix, 20% strand | O34824 |
| B | Phosphoglucosamine mutase (EC 5.4.2.10) | protein | 366 | 39% helix, 20% strand | O34824 |
| D, E | Phosphoglucosamine mutase (EC 5.4.2.10) | protein | 367 | 38% helix, 20% strand | O34824 |
| F | Phosphoglucosamine mutase (EC 5.4.2.10) | protein | 367 | 38% helix, 20% strand | O34824 |
| G, I, K | Cyclic di-AMP synthase cdaa (EC 2.7.7.85) | protein | 146 | 34% helix, 27% strand | Q45589 |
| H, L | Cyclic di-AMP synthase cdaa (EC 2.7.7.85) | protein | 144 | 35% helix, 24% strand | Q45589 |
| J | Cyclic di-AMP synthase cdaa (EC 2.7.7.85) | protein | 147 | 31% helix, 24% strand | Q45589 |
Pockets
20 pockets found on a 1 Å grid, 14 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 707 | 0.80 | 0.84 | 79 | empty |
| 2 | 443 | 0.75 | 0.84 | 50 | empty |
| 3 | 254 | 0.70 | 0.86 | 37 | empty |
| 4 | 301 | 0.70 | 0.84 | 37 | empty |
| 5 | 246 | 0.70 | 0.86 | 36 | empty |
Interfaces
20 interfaces between chains.
- A–B · 1244 Ų buried · 13 hydrogen bonds · protein-protein
- C–D · 1228 Ų buried · 16 hydrogen bonds · protein-protein
- E–F · 1214 Ų buried · 14 hydrogen bonds · protein-protein
- K–L · 768 Ų buried · 11 hydrogen bonds · protein-protein
- G–H · 768 Ų buried · 11 hydrogen bonds · protein-protein
Compared structures
- 7OLH · Bacillus subtilis Complex structure 1 of diadenylate cyclase CdaA cytoplasmic domain… · the same entry in another collection · chain L against L, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O34824
- Every structure of UniProt Q45589
- Elsewhere: RCSB PDB 7OLH · PDBe 7OLH · UniProt O34824 · UniProt Q45589
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