MolNFT v1 · #184190 · protein

Tetanus neurotoxin hc domain in complex with TT104-FAB1

7OH0 · Tetanus toxin: “Tetanus neurotoxin hc domain in complex with TT104-FAB1”. Electron microscopy, 15 pockets (best druggability 0.73). MolNFT v1 #184190 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 7OH0
Type: protein
Length: 870 residues
Chains: 3
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Tetanus toxin; Fab TT104
UniProt: C4PD05
Pockets: 15 · best druggability 0.73

Structure

electron microscopy · 3 distinct chains · 6% helix, 34% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Tetanus toxin	protein	435	8% helix, 36% strand	C4PD05
C	Fab TT104	protein	221	3% helix, 34% strand	—
B	Fab TT104	protein	214	7% helix, 27% strand	—

Pockets

15 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	62	0.73	0.97	25	empty
2	66	0.72	0.96	18	empty
3	266	0.67	0.83	40	empty
4	359	0.61	0.77	59	empty
5	170	0.56	0.81	26	empty

Interfaces

3 interfaces between chains.

C–B · 1823 Å² buried · 12 hydrogen bonds · protein-protein
A–C · 624 Å² buried · 12 hydrogen bonds · protein-protein
A–B · 438 Å² buried · 6 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 5 disulfide (disulfide).

Compared structures

7OH0 · Tetanus neurotoxin HC domain in complex with TT104-Fab1 · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt C4PD05
Elsewhere: RCSB PDB 7OH0 · PDBe 7OH0 · UniProt C4PD05

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.