MolNFT v1 · #184186 · protein + DNA
X-ray structure of interferon regulatory factor 4 DNA binding domain bound to an interferon-stimulated response element
7OGS: “X-ray structure of interferon regulatory factor 4 DNA binding domain bound to an interferon-stimulated…”. X-ray diffraction, 16 pockets (best druggability 0.53). MolNFT v1 #184186 on GenesisL1: 3D structure, binding sites and…
- PDB
- 7OGS
- Type
- protein + DNA
- Length
- 536 residues
- Chains
- 8
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Interferon regulatory factor 4; DNA (5'- D(P*TP*GP*TP*AP*CP*TP*TP*TP*CP*GP*GP*TP*TP*TP*CP*…
- UniProt
- Q15306
- Pockets
- 16 · best druggability 0.53
Structure
x-ray diffraction · 3 distinct chains · 33% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, E, F | Interferon regulatory factor 4 | protein | 114 | 33% helix, 15% strand | Q15306 |
| C, G | DNA (5'- D(P*TP*GP*TP*AP*CP*TP*TP*TP*CP*GP*GP*TP*TP*TP*CP*AP*GP*TP*TP*A)-3') | dna | 20 | — | — |
| D, H | DNA (5'- D(P*AP*TP*AP*AP*CP*TP*GP*AP*AP*AP*CP*CP*GP*AP*AP*AP*GP*TP*AP*C)-3') | dna | 20 | — | — |
Pockets
16 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 254 | 0.53 | 0.76 | 28 | empty |
| 2 | 257 | 0.50 | 0.75 | 28 | empty |
| 3 | 65 | 0.48 | 0.84 | 19 | empty |
| 4 | 58 | 0.47 | 0.84 | 18 | empty |
| 5 | 128 | 0.47 | 0.79 | 14 | empty |
Interfaces
11 interfaces between chains.
- G–H · 855 Ų buried · 87 hydrogen bonds · nucleic-nucleic
- C–D · 848 Ų buried · 81 hydrogen bonds · nucleic-nucleic
- B–C · 607 Ų buried · 8 hydrogen bonds · protein-nucleic
- F–G · 593 Ų buried · 7 hydrogen bonds · protein-nucleic
- E–G · 552 Ų buried · 8 hydrogen bonds · protein-nucleic
Compared structures
- 7OGS · X-ray Structure of Interferon Regulatory Factor 4 DNA binding domain bound to an… · the same entry in another collection · chain H against H, TM-score 1.00
- Q15306 · AlphaFold monomer V2.0 prediction for interferon regulatory factor 4 (Q15306) · a predicted model of the same protein · chain A against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q15306
- Elsewhere: RCSB PDB 7OGS · PDBe 7OGS · UniProt Q15306
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