MolNFT v1 · #184177 · protein
NSE5/6 complex
7OGG · Non-structural maintenance of chromosome element 5,NON…: “NSE5/6 complex”. X-ray diffraction, 13 pockets (best druggability 0.76). MolNFT v1 #184177 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7OGG
- Type
- protein
- Length
- 665 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Non-structural maintenance of chromosome element 5,NON- structural maintenance of…
- UniProt
- Q03718, P40026
- Pockets
- 13 · best druggability 0.76
Structure
x-ray diffraction · 2 distinct chains · 55% helix, 2% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| R | Non-structural maintenance of chromosome element 5,NON- structural maintenance of chromosome element 5,NON-structural maintenance of chromosome element 5 | protein | 458 | 54% helix, 2% strand | Q03718 |
| Q | DNA repair protein KRE29,DNA repair protein KRE29,DNA repair protein KRE29 | protein | 207 | 57% helix, 0% strand | P40026 |
Pockets
13 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 395 | 0.76 | 0.85 | 69 | empty |
| 2 | 84 | 0.76 | 0.98 | 21 | empty |
| 3 | 378 | 0.72 | 0.83 | 50 | empty |
| 4 | 402 | 0.65 | 0.79 | 35 | empty |
| 5 | 187 | 0.63 | 0.83 | 33 | empty |
Interfaces
1 interface between chains.
- R–Q · 1739 Ų buried · 15 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 10 modified (engineered).
Compared structures
- 7OGG · Nse5/6 complex · the same entry in another collection · chain R against R, TM-score 1.00
- P40026 · AlphaFold monomer V2.0 prediction for DNA repair protein KRE29 (P40026) · a predicted model of the same protein · chain Q against A, TM-score 0.88
- Q03718 · AlphaFold monomer V2.0 prediction for non-structural maintenance of chromosome element 5… · a predicted model of the same protein · chain R against A, TM-score 0.85
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q03718
- Every structure of UniProt P40026
- Elsewhere: RCSB PDB 7OGG · PDBe 7OGG · UniProt Q03718 · UniProt P40026
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