MolNFT v1 · #184159 · protein + RNA
Nontypeable haemophillus influenzae sapa in complex with heme
7OFW · ABC-type transport system, periplasmic component, involved…: “Nontypeable haemophillus influenzae sapa in complex with heme”. X-ray diffraction, 1 ligand (HEM), 8 pockets (best druggability 0.74). MolNFT v1 #184159 on GenesisL1: 3D…
- PDB
- 7OFW
- Type
- protein + RNA
- Length
- 511 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- ABC-type transport system, periplasmic component, involved in antimicrobial peptide…
- UniProt
- Q4QL73
- Ligands
- HEM
- Pockets
- 8 · best druggability 0.74
Structure
x-ray diffraction · 2 distinct chains · 27% helix, 23% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | ABC-type transport system, periplasmic component, involved in antimicrobial peptide resistance | protein | 493 | 27% helix, 23% strand | Q4QL73 |
| C | RNA (5'- R(P*CP*CP*CP*CP*CP*CP*CP*CP*CP*GP*GP*GP*GP*GP*GP*GP*GP*G)-3') | rna | 18 | — | — |
Ligands and binding sites
- HEM · Protoporphyrin IX containing Fe · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
8 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 75 | 0.74 | 0.97 | 25 | empty |
| 2 | 85 | 0.71 | 0.95 | 20 | empty |
| 3 | 251 | 0.71 | 0.86 | 51 | empty |
| 4 | 71 | 0.58 | 0.88 | 23 | empty |
| 5 | 161 | 0.52 | 0.79 | 25 | empty |
Interfaces
1 interface between chains.
- A–C · 233 Ų buried · 8 hydrogen bonds · protein-nucleic
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
- 7OFW · Nontypeable Haemophillus influenzae SapA in complex with heme · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q4QL73
- Elsewhere: RCSB PDB 7OFW · PDBe 7OFW · UniProt Q4QL73
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.