MolNFT v1 · #184147 · protein
Cryoem structure of the outer membrane secretin pore piv from the F1 filamentous bacteriophage.
7OFH · Virion export protein: “Cryoem structure of the outer membrane secretin pore piv from the F1 filamentous bacteriophage.”. Electron microscopy, 1 ligand (CPS), 20 pockets (best druggability 0.69). MolNFT v1 #184147 on GenesisL1: 3D…
- PDB
- 7OFH
- Type
- protein
- Length
- 3,465 residues
- Chains
- 15
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Virion export protein
- UniProt
- P03666
- Ligands
- CPS
- Pockets
- 20 · best druggability 0.69
Structure
electron microscopy · 1 distinct chain · 6% helix, 58% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E, F, G, H, I, J, K, L, M, N, O | Virion export protein | protein | 231 | 6% helix, 58% strand | P03666 |
Ligands and binding sites
- CPS · 3-[(3-cholamidopropyl)dimethylammonio]-1-propanesulfonate · ligand · 30 copies · chains A, O, B, C, D, E, F, G, H, I, J, K, L, M, N
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 686 | 0.69 | 0.77 | 90 | empty |
| 2 | 697 | 0.69 | 0.77 | 83 | empty |
| 3 | 482 | 0.65 | 0.77 | 58 | empty |
| 4 | 463 | 0.64 | 0.77 | 62 | empty |
| 5 | 428 | 0.63 | 0.77 | 55 | empty |
Interfaces
15 interfaces between chains.
- A–O · 2599 Ų buried · 42 hydrogen bonds · protein-protein
- G–H · 2596 Ų buried · 42 hydrogen bonds · protein-protein
- N–O · 2595 Ų buried · 42 hydrogen bonds · protein-protein
- F–G · 2594 Ų buried · 41 hydrogen bonds · protein-protein
- B–C · 2594 Ų buried · 42 hydrogen bonds · protein-protein
Compared structures
- 7OFH · CryoEM structure of the outer membrane secretin pore pIV from the f1 filamentous… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P03666
- Elsewhere: RCSB PDB 7OFH · PDBe 7OFH · UniProt P03666
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