MolNFT v1 · #184138 · protein

Mevalonyl-coenzyme a hydratase (sid H)

7OEQ · Mevalonyl-coenzyme a hydratase sidh: “Mevalonyl-coenzyme a hydratase (sid H)”. X-ray diffraction, 2 pockets (best druggability 0.58). MolNFT v1 #184138 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 7OEQ
Type: protein
Length: 259 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Mevalonyl-coenzyme a hydratase sidh
EC: 4.2.1.-
UniProt: Q4WF54
Pockets: 2 · best druggability 0.58

Structure

x-ray diffraction · 1 distinct chain · 47% helix, 17% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Mevalonyl-coenzyme a hydratase sidh (EC 4.2.1.-)	protein	259	47% helix, 17% strand	Q4WF54

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	226	0.58	0.79	33	empty
2	172	0.48	0.76	24	empty

Compared structures

7OEQ · Mevalonyl-coenzyme A hydratase (Sid H) · the same entry in another collection · chain A against A, TM-score 1.00
Q4WF54 · AlphaFold monomer V2.0 prediction for mevalonyl-coenzyme a hydratase sidh (Q4WF54) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q4WF54
Elsewhere: RCSB PDB 7OEQ · PDBe 7OEQ · UniProt Q4WF54

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