MolNFT v1 · #184118 · protein + RNA

30S ribosomal subunit from E. COLI

7OE1 · 16S rRNA: “30S ribosomal subunit from E. COLI”. Electron microscopy, 20 pockets (best druggability 0.87). MolNFT v1 #184118 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 7OE1
Type: protein + RNA
Length: 3,850 residues
Chains: 21
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: 16S rRNA; 30S ribosomal protein S4; 30S ribosomal protein S5; 30S ribosomal protein S6…
UniProt: A0A6D2XM56, A0A6D2YBZ5, P02358, A0A6D2XYQ3, A0A6D2X4T2, A0A4S5B3M5, C3SSQ8, A0A6D2XXS6, A0A4S5APA8, A0A6D2XHZ3, A0A4S5B3X7, A0A6D2W584, A0A5F1E8X4, A0A6D2XYP0, C4ZUJ6, A0A6D2XBM7, A0A6D2XQX6, A0A6D2XQ78, A0A6D2WD65, E3PL00
Pockets: 20 · best druggability 0.87

Structure

electron microscopy · 21 distinct chains · 34% helix, 15% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	16S rRNA	rna	1530	—	—
D	30S ribosomal protein S4	protein	205	36% helix, 9% strand	A0A6D2XM56
E	30S ribosomal protein S5	protein	150	27% helix, 22% strand	A0A6D2YBZ5
F	30S ribosomal protein S6, fully modified isoform	protein	100	32% helix, 22% strand	P02358
H	30S ribosomal protein S8	protein	129	22% helix, 29% strand	A0A6D2XYQ3
K	30S ribosomal protein S11	protein	117	27% helix, 30% strand	A0A6D2X4T2
L	30S ribosomal protein S12	protein	123	7% helix, 15% strand	A0A4S5B3M5
O	30S ribosomal protein S15	protein	88	73% helix, 0% strand	C3SSQ8
P	30S ribosomal protein S16	protein	82	28% helix, 27% strand	A0A6D2XXS6
Q	30S ribosomal protein S17	protein	80	0% helix, 58% strand	A0A4S5APA8
R	30S ribosomal protein S18	protein	55	40% helix, 4% strand	A0A6D2XHZ3
T	30S ribosomal protein S20	protein	85	80% helix, 0% strand	A0A4S5B3X7
B	30S ribosomal protein S2	protein	218	48% helix, 7% strand	A0A6D2W584
U	30S ribosomal protein S21	protein	18	44% helix, 0% strand	A0A5F1E8X4
C	30S ribosomal protein S3	protein	206	33% helix, 19% strand	A0A6D2XYP0
G	30S ribosomal protein S7	protein	150	38% helix, 3% strand	C4ZUJ6
I	30S ribosomal protein S9	protein	127	23% helix, 18% strand	A0A6D2XBM7
J	30S ribosomal protein S10	protein	98	22% helix, 18% strand	A0A6D2XQX6
M	30S ribosomal protein S13	protein	114	50% helix, 0% strand	A0A6D2XQ78
N	30S ribosomal protein S14	protein	96	46% helix, 2% strand	A0A6D2WD65
S	30S ribosomal protein S19	protein	79	14% helix, 14% strand	E3PL00

Pockets

20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	495	0.87	0.94	75	empty
2	863	0.84	0.87	73	empty
3	867	0.83	0.86	69	empty
4	747	0.83	0.88	61	empty
5	302	0.82	0.93	49	empty

Interfaces

38 interfaces between chains.

A–D · 3238 Å² buried · 86 hydrogen bonds · protein-nucleic
A–L · 2994 Å² buried · 75 hydrogen bonds · protein-nucleic
A–I · 2866 Å² buried · 97 hydrogen bonds · protein-nucleic
A–G · 2365 Å² buried · 96 hydrogen bonds · protein-nucleic
A–T · 2331 Å² buried · 45 hydrogen bonds · protein-nucleic

Compared structures

7OE1 · 30S ribosomal subunit from E. coli · the same entry in another collection · chain S against S, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt A0A6D2XM56
Every structure of UniProt A0A6D2YBZ5
Every structure of UniProt P02358
Every structure of UniProt A0A6D2XYQ3
Every structure of UniProt A0A6D2X4T2
Every structure of UniProt A0A4S5B3M5
Every structure of UniProt C3SSQ8
Every structure of UniProt A0A6D2XXS6
Every structure of UniProt A0A4S5APA8
Every structure of UniProt A0A6D2XHZ3
Every structure of UniProt A0A4S5B3X7
Every structure of UniProt A0A6D2W584
Every structure of UniProt A0A5F1E8X4
Every structure of UniProt A0A6D2XYP0
Every structure of UniProt C4ZUJ6
Every structure of UniProt A0A6D2XBM7
Every structure of UniProt A0A6D2XQX6
Every structure of UniProt A0A6D2XQ78
Every structure of UniProt A0A6D2WD65
Every structure of UniProt E3PL00
Elsewhere: RCSB PDB 7OE1 · PDBe 7OE1 · UniProt A0A6D2XM56 · UniProt A0A6D2YBZ5 · UniProt P02358 · UniProt A0A6D2XYQ3 · UniProt A0A6D2X4T2 · UniProt A0A4S5B3M5 · UniProt C3SSQ8 · UniProt A0A6D2XXS6 · UniProt A0A4S5APA8 · UniProt A0A6D2XHZ3 · UniProt A0A4S5B3X7 · UniProt A0A6D2W584 · UniProt A0A5F1E8X4 · UniProt A0A6D2XYP0 · UniProt C4ZUJ6 · UniProt A0A6D2XBM7 · UniProt A0A6D2XQX6 · UniProt A0A6D2XQ78 · UniProt A0A6D2WD65 · UniProt E3PL00

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