MolNFT v1 · #184003 · protein
Crystal structure of human menin in complex with fragment 21
7OA9 · Isoform 2 of menin: “Crystal structure of human menin in complex with fragment 21”. X-ray diffraction, 1 ligand (V6K), 1 pocket (best druggability 0.66). MolNFT v1 #184003 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 7OA9
- Type
- protein
- Length
- 456 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Isoform 2 of menin
- UniProt
- O00255
- Ligands
- V6K
- Pockets
- 1 · best druggability 0.66
Structure
x-ray diffraction · 1 distinct chain · 57% helix, 6% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Isoform 2 of menin | protein | 456 | 57% helix, 6% strand | O00255 |
Ligands and binding sites
- V6K · (~{E})-2-cyano-3-(4-hydroxyphenyl)-~{N}-(2-morpholin-4-ylethyl)prop-2-enamide · ligand · chains A
- EDO · 1,2-ethanediol · additive · 7 copies · chains A
- GOL · Glycerol · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 505 | 0.66 | 0.77 | 57 | V6K, GOL |
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O00255
- Elsewhere: RCSB PDB 7OA9 · PDBe 7OA9 · UniProt O00255
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.