MolNFT v1 · #183891 · protein
2.12 a cryo-EM structure of mycobacterium tuberculosis ferritin
7O6E · Ferritin bfrb: “2.12 a cryo-EM structure of mycobacterium tuberculosis ferritin”. Electron microscopy, 20 pockets (best druggability 0.84). MolNFT v1 #183891 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7O6E
- Type
- protein
- Length
- 4,248 residues
- Chains
- 24
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Ferritin bfrb
- EC
- 1.16.3.1
- UniProt
- P9WNE5
- Pockets
- 20 · best druggability 0.84
Structure
electron microscopy · 1 distinct chain · 71% helix, 1% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, V, W, X, Y | Ferritin bfrb (EC 1.16.3.1) | protein | 177 | 71% helix, 1% strand | P9WNE5 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1050 | 0.84 | 0.85 | 126 | empty |
| 2 | 951 | 0.84 | 0.85 | 119 | empty |
| 3 | 1065 | 0.84 | 0.85 | 130 | empty |
| 4 | 904 | 0.83 | 0.85 | 103 | empty |
| 5 | 855 | 0.83 | 0.85 | 97 | empty |
Interfaces
60 interfaces between chains.
- D–W · 1167 Ų buried · 9 hydrogen bonds · protein-protein
- F–O · 1167 Ų buried · 9 hydrogen bonds · protein-protein
- I–Q · 1167 Ų buried · 9 hydrogen bonds · protein-protein
- J–N · 1167 Ų buried · 9 hydrogen bonds · protein-protein
- C–X · 1167 Ų buried · 9 hydrogen bonds · protein-protein
Compared structures
- 7O6E · 2.12 A cryo-EM structure of Mycobacterium tuberculosis Ferritin · the same entry in another collection · chain G against G, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P9WNE5
- Elsewhere: RCSB PDB 7O6E · PDBe 7O6E · UniProt P9WNE5
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