MolNFT v1 · #183875 · protein
Pila minor pilin of streptococcus sanguinis type IV pili
7O5Y · Type IV pilus biogenesis protein pila: “Pila minor pilin of streptococcus sanguinis type IV pili”. X-ray diffraction, 1 ligand (CL), 3 pockets (best druggability 0.44). MolNFT v1 #183875 on GenesisL1: 3D structure, binding sites and…
- PDB
- 7O5Y
- Type
- protein
- Length
- 514 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Type IV pilus biogenesis protein pila
- UniProt
- A0A0B7GNW3
- Ligands
- CL
- Pockets
- 3 · best druggability 0.44
Structure
x-ray diffraction · 4 distinct chains · 31% helix, 36% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B | Type IV pilus biogenesis protein pila | protein | 128 | 31% helix, 36% strand | A0A0B7GNW3 |
| C | Type IV pilus biogenesis protein pila | protein | 129 | 31% helix, 36% strand | A0A0B7GNW3 |
| D | Type IV pilus biogenesis protein pila | protein | 131 | 31% helix, 35% strand | A0A0B7GNW3 |
| A | Type IV pilus biogenesis protein pila | protein | 126 | 32% helix, 37% strand | A0A0B7GNW3 |
Ligands and binding sites
- CL · Chloride ion · ion · 2 copies · chains B, C, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 132 | 0.44 | 0.76 | 23 | empty |
| 2 | 113 | 0.38 | 0.75 | 23 | empty |
| 3 | 83 | 0.31 | 0.73 | 20 | empty |
Interfaces
5 interfaces between chains.
- B–C · 1358 Ų buried · 11 hydrogen bonds · protein-protein
- C–A · 276 Ų buried · 5 hydrogen bonds · protein-protein
- B–D · 253 Ų buried · 4 hydrogen bonds · protein-protein
- C–D · 214 Ų buried · 1 hydrogen bond · protein-protein
- B–A · 197 Ų buried · 1 hydrogen bond · protein-protein
Modifications
Observed in the structure: 8 modified (engineered).
Compared structures
- 7O5Y · PilA minor pilin of Streptococcus sanguinis type IV pili · the same entry in another collection · chain B against B, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A0B7GNW3
- Elsewhere: RCSB PDB 7O5Y · PDBe 7O5Y · UniProt A0A0B7GNW3
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