MolNFT v1 · #183855 · protein + DNA
X-ray structure of interferon regulatory factor 4 DNA binding domain bound to an interferon-stimulated response element solved by phosphorus and sulphur sad methods
7O56: “X-ray structure of interferon regulatory factor 4 DNA binding domain bound to an interferon-stimulated…”. X-ray diffraction, 7 pockets (best druggability 0.68). MolNFT v1 #183855 on GenesisL1: 3D structure, binding sites and pockets…
- PDB
- 7O56
- Type
- protein + DNA
- Length
- 377 residues
- Chains
- 5
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Interferon regulatory factor 4; DNA (5'- D(P*AP*AP*TP*AP*AP*AP*AP*GP*AP*AP*AP*CP*CP*GP*AP*…
- UniProt
- Q15306
- Pockets
- 7 · best druggability 0.68
Structure
x-ray diffraction · 5 distinct chains · 34% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Interferon regulatory factor 4 | protein | 114 | 33% helix, 15% strand | Q15306 |
| D | DNA (5'- D(P*AP*AP*TP*AP*AP*AP*AP*GP*AP*AP*AP*CP*CP*GP*AP*AP*AP*GP*TP*AP*A)- 3') | dna | 21 | — | — |
| E | DNA (5'- D(P*TP*TP*TP*AP*CP*TP*TP*TP*CP*GP*GP*TP*TP*TP*CP*TP*TP*TP*TP*AP*T)- 3') | dna | 21 | — | — |
| B | Interferon regulatory factor 4 | protein | 109 | 35% helix, 16% strand | Q15306 |
| C | Interferon regulatory factor 4 | protein | 112 | 34% helix, 14% strand | Q15306 |
Pockets
7 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 656 | 0.68 | 0.77 | 55 | empty |
| 2 | 311 | 0.53 | 0.75 | 34 | empty |
| 3 | 54 | 0.46 | 0.84 | 19 | empty |
| 4 | 100 | 0.42 | 0.78 | 14 | empty |
| 5 | 114 | 0.40 | 0.76 | 17 | empty |
Interfaces
7 interfaces between chains.
- D–E · 884 Ų buried · 73 hydrogen bonds · nucleic-nucleic
- E–B · 628 Ų buried · 11 hydrogen bonds · protein-nucleic
- A–E · 596 Ų buried · 13 hydrogen bonds · protein-nucleic
- D–B · 431 Ų buried · 9 hydrogen bonds · protein-nucleic
- A–D · 412 Ų buried · 7 hydrogen bonds · protein-nucleic
Compared structures
- 7O56 · X-ray Structure of Interferon Regulatory Factor 4 DNA binding domain bound to an… · the same entry in another collection · chain E against E, TM-score 1.00
- Q15306 · AlphaFold monomer V2.0 prediction for interferon regulatory factor 4 (Q15306) · a predicted model of the same protein · chain B against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q15306
- Elsewhere: RCSB PDB 7O56 · PDBe 7O56 · UniProt Q15306
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.