MolNFT v1 · #183817 · protein
Hexameric composite model of the inner membrane complex (imc) with the arches from the fully-assembled R388 type IV secretion system determined by cryo-EM.
7O41 · Trwm protein: “Hexameric composite model of the inner membrane complex (imc) with the arches from the fully-assembled R388…”. Electron microscopy, 20 pockets (best druggability 0.75). MolNFT v1 #183817 on GenesisL1: 3D structure…
- PDB
- 7O41
- Type
- protein
- Length
- 2,094 residues
- Chains
- 6
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Trwm protein; Trwk protein; Trwg protein
- UniProt
- O50329, O50330, O50335
- Pockets
- 20 · best druggability 0.75
Structure
electron microscopy · 6 distinct chains · 41% helix, 20% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| C | Trwm protein | protein | 104 | 46% helix, 3% strand | O50329 |
| A | Trwk protein | protein | 752 | 40% helix, 18% strand | O50330 |
| B | Trwk protein | protein | 685 | 39% helix, 20% strand | O50330 |
| D | Trwg protein | protein | 187 | 47% helix, 26% strand | O50335 |
| E | Trwg protein | protein | 188 | 45% helix, 26% strand | O50335 |
| F | Trwg protein | protein | 178 | 47% helix, 27% strand | O50335 |
Pockets
20 pockets found on a 1 Å grid, 19 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 649 | 0.75 | 0.81 | 75 | empty |
| 2 | 62 | 0.72 | 0.97 | 17 | empty |
| 3 | 75 | 0.71 | 0.96 | 25 | empty |
| 4 | 101 | 0.71 | 0.93 | 26 | empty |
| 5 | 54 | 0.70 | 0.97 | 18 | empty |
Interfaces
10 interfaces between chains.
- C–A · 2708 Ų buried · 33 hydrogen bonds · protein-protein
- A–B · 1757 Ų buried · 11 hydrogen bonds · protein-protein
- D–E · 858 Ų buried · 12 hydrogen bonds · protein-protein
- B–D · 648 Ų buried · 9 hydrogen bonds · protein-protein
- B–E · 562 Ų buried · 4 hydrogen bonds · protein-protein
Compared structures
- 7O41 · Hexameric composite model of the Inner Membrane Complex (IMC) with the Arches from the… · the same entry in another collection · chain F against F, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O50329
- Every structure of UniProt O50330
- Every structure of UniProt O50335
- Elsewhere: RCSB PDB 7O41 · PDBe 7O41 · UniProt O50329 · UniProt O50330 · UniProt O50335
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