MolNFT v1 · #183802 · protein
Crystal structure of acrb single mutant - 1
7O3M · Efflux pump membrane transporter: “Crystal structure of acrb single mutant - 1”. X-ray diffraction, 20 pockets (best druggability 0.87). MolNFT v1 #183802 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7O3M
- Type
- protein
- Length
- 6,260 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Efflux pump membrane transporter
- UniProt
- E2QH56
- Pockets
- 20 · best druggability 0.87
Structure
x-ray diffraction · 2 distinct chains · 49% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C, D, F | Efflux pump membrane transporter | protein | 1044 | 49% helix, 17% strand | E2QH56 |
| B, E | Efflux pump membrane transporter | protein | 1042 | 50% helix, 17% strand | E2QH56 |
Ligands and binding sites
- LMT · Dodecyl-beta-D-maltoside · additive · 6 copies · chains A, B, C, D, E, F
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1181 | 0.87 | 0.88 | 128 | empty |
| 2 | 714 | 0.85 | 0.89 | 86 | empty |
| 3 | 610 | 0.85 | 0.90 | 83 | empty |
| 4 | 1055 | 0.84 | 0.86 | 117 | empty |
| 5 | 658 | 0.84 | 0.88 | 102 | empty |
Interfaces
8 interfaces between chains.
- D–E · 3621 Ų buried · 47 hydrogen bonds · protein-protein
- D–F · 3602 Ų buried · 38 hydrogen bonds · protein-protein
- A–B · 3476 Ų buried · 38 hydrogen bonds · protein-protein
- A–C · 3404 Ų buried · 37 hydrogen bonds · protein-protein
- B–C · 2963 Ų buried · 40 hydrogen bonds · protein-protein
Compared structures
- 7O3M · Crystal Structure of AcrB Single Mutant - 1 · the same entry in another collection · chain F against F, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt E2QH56
- Elsewhere: RCSB PDB 7O3M · PDBe 7O3M · UniProt E2QH56
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