MolNFT v1 · #183794 · protein
Cooperation between the intrinsically disordered and ordered regions of SPT6 regulates nucleosome and pol II ctd binding, and nucleosome assembly
7O3D · Transcription elongation factor SPT6: “Cooperation between the intrinsically disordered and ordered regions of SPT6 regulates nucleosome and pol II…”. Electron microscopy, 12 pockets (best druggability 0.72). MolNFT v1 #183794 on…
- PDB
- 7O3D
- Type
- protein
- Length
- 709 residues
- Chains
- 1
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Transcription elongation factor SPT6
- UniProt
- P23615
- Pockets
- 12 · best druggability 0.72
Structure
electron microscopy · 1 distinct chain · 50% helix, 9% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Transcription elongation factor SPT6 | protein | 709 | 50% helix, 9% strand | P23615 |
Pockets
12 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 537 | 0.72 | 0.81 | 45 | empty |
| 2 | 546 | 0.70 | 0.79 | 54 | empty |
| 3 | 506 | 0.69 | 0.79 | 50 | empty |
| 4 | 68 | 0.67 | 0.94 | 22 | empty |
| 5 | 220 | 0.57 | 0.79 | 27 | empty |
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 7O3D · Cooperation between the intrinsically disordered and ordered regions of Spt6 regulates… · the same entry in another collection · chain A against A, TM-score 1.00
- P23615 · AlphaFold monomer V2.0 prediction for transcription elongation factor SPT6 (P23615) · a predicted model of the same protein · chain A against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P23615
- Elsewhere: RCSB PDB 7O3D · PDBe 7O3D · UniProt P23615
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