MolNFT v1 · #183723 · protein

ABC transporter nosdfy, nucleotide-free in lipid nanodisc, R-domain 1

7O14 · Probable ABC transporter ATP-binding protein nosf: “ABC transporter nosdfy, nucleotide-free in lipid nanodisc, R-domain 1”. Electron microscopy, 1 ligand (MG), 15 pockets (best druggability 0.79). MolNFT v1 #183723 on GenesisL1: 3D…

PDB: 7O14
Type: protein
Length: 1,531 residues
Chains: 5
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Probable ABC transporter ATP-binding protein nosf; Probable ABC transporter permease…
UniProt: P19844, P19845, P19843
Ligands: MG
Pockets: 15 · best druggability 0.79

Structure

electron microscopy · 4 distinct chains · 42% helix, 17% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
B, C	Probable ABC transporter ATP-binding protein nosf	protein	307	31% helix, 19% strand	P19844
D	Probable ABC transporter permease protein nosy	protein	267	78% helix, 0% strand	P19845
E	Probable ABC transporter permease protein nosy	protein	248	77% helix, 0% strand	P19845
A	Probable ABC transporter binding protein nosd	protein	402	7% helix, 36% strand	P19843

Ligands and binding sites

MG · Magnesium ion · metal · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

15 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	889	0.79	0.81	73	empty
2	883	0.79	0.82	98	empty
3	683	0.72	0.79	59	empty
4	254	0.67	0.84	30	empty
5	111	0.63	0.87	19	empty

Interfaces

7 interfaces between chains.

B–C · 2814 Å² buried · 35 hydrogen bonds · protein-protein
C–D · 1154 Å² buried · 14 hydrogen bonds · protein-protein
B–E · 1136 Å² buried · 6 hydrogen bonds · protein-protein
D–A · 912 Å² buried · 8 hydrogen bonds · protein-protein
E–A · 850 Å² buried · 4 hydrogen bonds · protein-protein

Compared structures

7O14 · ABC transporter NosDFY, nucleotide-free in lipid nanodisc, R-domain 1 · the same entry in another collection · chain A against A, TM-score 1.00
P19843 · AlphaFold monomer V2.0 prediction for probable ABC transporter binding protein nosd… · a predicted model of the same protein · chain A against A, TM-score 0.96
P19845 · AlphaFold monomer V2.0 prediction for probable ABC transporter permease protein nosy… · a predicted model of the same protein · chain E against A, TM-score 0.95
P19844 · AlphaFold monomer V2.0 prediction for probable ABC transporter ATP- binding protein nosf… · a predicted model of the same protein · chain B against A, TM-score 0.89

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P19844
Every structure of UniProt P19845
Every structure of UniProt P19843
Elsewhere: RCSB PDB 7O14 · PDBe 7O14 · UniProt P19844 · UniProt P19845 · UniProt P19843

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