MolNFT v1 · #183721 · protein
ABC transporter nosdfy, nucleotide-free in gdn, R-domain 1
7O11 · Probable ABC transporter binding protein nosd: “ABC transporter nosdfy, nucleotide-free in gdn, R-domain 1”. Electron microscopy, 1 ligand (MG), 12 pockets (best druggability 0.78). MolNFT v1 #183721 on GenesisL1: 3D structure…
- PDB
- 7O11
- Type
- protein
- Length
- 1,514 residues
- Chains
- 5
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Probable ABC transporter binding protein nosd; Probable ABC transporter ATP-binding…
- UniProt
- P19843, P19844, P19845
- Ligands
- MG
- Pockets
- 12 · best druggability 0.78
Structure
electron microscopy · 5 distinct chains · 39% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Probable ABC transporter binding protein nosd | protein | 402 | 6% helix, 35% strand | P19843 |
| B | Probable ABC transporter ATP-binding protein nosf | protein | 299 | 29% helix, 19% strand | P19844 |
| C | Probable ABC transporter ATP-binding protein nosf | protein | 298 | 30% helix, 22% strand | P19844 |
| D | Probable ABC transporter permease protein nosy | protein | 267 | 77% helix, 0% strand | P19845 |
| E | Probable ABC transporter permease protein nosy | protein | 248 | 76% helix, 0% strand | P19845 |
Ligands and binding sites
- MG · Magnesium ion · metal · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
12 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1004 | 0.78 | 0.80 | 84 | empty |
| 2 | 512 | 0.77 | 0.84 | 48 | empty |
| 3 | 350 | 0.76 | 0.87 | 48 | empty |
| 4 | 243 | 0.62 | 0.81 | 30 | empty |
| 5 | 211 | 0.56 | 0.79 | 36 | empty |
Interfaces
7 interfaces between chains.
- B–C · 1754 Ų buried · 29 hydrogen bonds · protein-protein
- C–D · 1195 Ų buried · 18 hydrogen bonds · protein-protein
- B–E · 1175 Ų buried · 16 hydrogen bonds · protein-protein
- A–D · 978 Ų buried · 14 hydrogen bonds · protein-protein
- A–E · 878 Ų buried · 5 hydrogen bonds · protein-protein
Compared structures
- 7O11 · ABC transporter NosDFY, nucleotide-free in GDN, R-domain 1 · the same entry in another collection · chain E against E, TM-score 1.00
- P19844 · AlphaFold monomer V2.0 prediction for probable ABC transporter ATP- binding protein nosf… · a predicted model of the same protein · chain B against A, TM-score 0.96
- P19843 · AlphaFold monomer V2.0 prediction for probable ABC transporter binding protein nosd… · a predicted model of the same protein · chain A against A, TM-score 0.96
- P19845 · AlphaFold monomer V2.0 prediction for probable ABC transporter permease protein nosy… · a predicted model of the same protein · chain D against A, TM-score 0.94
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P19843
- Every structure of UniProt P19844
- Every structure of UniProt P19845
- Elsewhere: RCSB PDB 7O11 · PDBe 7O11 · UniProt P19843 · UniProt P19844 · UniProt P19845
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