MolNFT v1 · #183717 · protein

Crystal structure of the N-terminal domain of CEP164(1-109) bound to camelid nanobody 36Z

7O0S: “Crystal structure of the N-terminal domain of CEP164(1-109) bound to camelid nanobody 36Z”. X-ray diffraction, 1 pocket (best druggability 0.49). MolNFT v1 #183717 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 7O0S
Type: protein
Length: 220 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Nanobody 36Z; Centrosomal protein of 164 kda
UniProt: Q9UPV0
Pockets: 1 · best druggability 0.49

Structure

x-ray diffraction · 2 distinct chains · 17% helix, 36% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Nanobody 36Z	protein	117	3% helix, 53% strand	—
B	Centrosomal protein of 164 kda	protein	103	34% helix, 17% strand	Q9UPV0

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	216	0.49	0.75	20	empty

Interfaces

1 interface between chains.

A–B · 1263 Å² buried · 24 hydrogen bonds · protein-protein

Compared structures

7O0S · Crystal structure of the N-terminal domain of CEP164(1-109) bound to camelid nanobody 36Z · the same entry in another collection · chain A against A, TM-score 1.00
Q9UPV0 · AlphaFold monomer V2.0 prediction for centrosomal protein of 164 kda (Q9UPV0) · a predicted model of the same protein · chain B against A, TM-score 0.87

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9UPV0
Elsewhere: RCSB PDB 7O0S · PDBe 7O0S · UniProt Q9UPV0

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