MolNFT v1 · #18371 · protein

Pleckstrin homology domain of son of sevenless 1 (SOS1) with glycine- serine added to the N-terminus, NMR, 20 structures

1PMS · Sos 1: “Pleckstrin homology domain of son of sevenless 1 (SOS1) with glycine- serine added to the N-terminus, NMR, 20…”. Solution nmr, 1 pocket (best druggability 0.52). MolNFT v1 #18371 on GenesisL1: 3D structure, binding sites and…

PDB: 1PMS
Type: protein
Length: 135 residues
Chains: 1
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Sos 1
UniProt: Q62245
Pockets: 1 · best druggability 0.52

Structure

solution nmr · 1 distinct chain · 17% helix, 27% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Sos 1	protein	135	17% helix, 27% strand	Q62245

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	78	0.52	0.85	17	empty

Compared structures

1PMS · Pleckstrin homology domain of son of sevenless 1 (SOS1) with glycine-serine added to the… · the same entry in another collection · chain A against A, TM-score 1.00
Q62245 · AlphaFold monomer V2.0 prediction for son of sevenless homolog 1 (Q62245) · a predicted model of the same protein · chain A against A, TM-score 0.64

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q62245
Elsewhere: RCSB PDB 1PMS · PDBe 1PMS · UniProt Q62245

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