MolNFT v1 · #183675 · protein
Crystal structure of mouse ADAT2/ADAT3 tRNA deamination complex 1
7NZ7 · TRNA-specific adenosine deaminase 2: “Crystal structure of mouse ADAT2/ADAT3 tRNA deamination complex 1”. X-ray diffraction, 1 ligand (ZN), 4 pockets (best druggability 0.70). MolNFT v1 #183675 on GenesisL1: 3D structure, binding…
- PDB
- 7NZ7
- Type
- protein
- Length
- 449 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- TRNA-specific adenosine deaminase 2; Probable inactive tRNA-specific adenosine…
- EC
- 3.5.4.33
- UniProt
- Q6P6J0, Q6PAT0
- Ligands
- ZN
- Pockets
- 4 · best druggability 0.70
Structure
x-ray diffraction · 2 distinct chains · 32% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | TRNA-specific adenosine deaminase 2 (EC 3.5.4.33) | protein | 166 | 42% helix, 18% strand | Q6P6J0 |
| B | Probable inactive tRNA-specific adenosine deaminase-like protein 3 | protein | 283 | 27% helix, 23% strand | Q6PAT0 |
Ligands and binding sites
- ZN · Zinc ion · metal · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 264 | 0.70 | 0.85 | 34 | ZN |
| 2 | 157 | 0.47 | 0.77 | 24 | empty |
| 3 | 72 | 0.43 | 0.81 | 13 | empty |
| 4 | 109 | 0.37 | 0.74 | 18 | empty |
Interfaces
1 interface between chains.
- A–B · 1267 Ų buried · 10 hydrogen bonds · protein-protein
Compared structures
- 7NZ7 · Crystal structure of mouse ADAT2/ADAT3 tRNA deamination complex 1 · the same entry in another collection · chain A against A, TM-score 1.00
- Q6P6J0 · AlphaFold monomer V2.0 prediction for tRNA-specific adenosine deaminase 2 (Q6P6J0) · a predicted model of the same protein · chain A against A, TM-score 0.94
- Q6PAT0 · AlphaFold monomer V2.0 prediction for probable inactive tRNA-specific adenosine… · a predicted model of the same protein · chain B against A, TM-score 0.60
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q6P6J0
- Every structure of UniProt Q6PAT0
- Elsewhere: RCSB PDB 7NZ7 · PDBe 7NZ7 · UniProt Q6P6J0 · UniProt Q6PAT0
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.