MolNFT v1 · #183650 · protein

Crystal structure of the capsaspora owczarzaki MACROH2A macrodomain in complex with ADP-ribose

7NY7 · Histone MACROH2A1.1: “Crystal structure of the capsaspora owczarzaki MACROH2A macrodomain in complex with ADP-ribose”. X-ray diffraction, 1 ligand (APR), 2 pockets (best druggability 0.60). MolNFT v1 #183650 on GenesisL1: 3D…

PDB: 7NY7
Type: protein
Length: 176 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Histone MACROH2A1.1
UniProt: A0A0D2UG83
Ligands: APR
Pockets: 2 · best druggability 0.60

Structure

x-ray diffraction · 1 distinct chain · 36% helix, 23% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Histone MACROH2A1.1	protein	176	36% helix, 23% strand	A0A0D2UG83

Ligands and binding sites

APR · Adenosine-5-diphosphoribose · ligand · chains A
EDO · 1,2-ethanediol · additive · 3 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	212	0.60	0.81	29	APR, EDO
2	81	0.38	0.76	14	empty

Compared structures

7NY7 · Crystal structure of the Capsaspora owczarzaki macroH2A macrodomain in complex with… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt A0A0D2UG83
Elsewhere: RCSB PDB 7NY7 · PDBe 7NY7 · UniProt A0A0D2UG83

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