MolNFT v1 · #183571 · protein + RNA
Rhinovirus 14 virion-like at pH 6.2
7NUQ · Genome polyprotein: “Rhinovirus 14 virion-like at pH 6.2”. Electron microscopy, 11 pockets (best druggability 0.79). MolNFT v1 #183571 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7NUQ
- Type
- protein + RNA
- Length
- 813 residues
- Chains
- 5
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Genome polyprotein; Octanucleotide
- EC
- 3.4.22.29, 3.6.1.15, 3.4.22.28, 2.7.7.48
- UniProt
- P03303
- Pockets
- 11 · best druggability 0.79
Structure
electron microscopy · 5 distinct chains · 10% helix, 30% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| 1 | Genome polyprotein (EC 3.4.22.29, 3.6.1.15, 3.4.22.28, 2.7.7.48) | protein | 273 | 8% helix, 27% strand | P03303 |
| 2 | Genome polyprotein (EC 3.4.22.29, 3.6.1.15, 3.4.22.28, 2.7.7.48) | protein | 256 | 13% helix, 34% strand | P03303 |
| 3 | Genome polyprotein (EC 3.4.22.29, 3.6.1.15, 3.4.22.28, 2.7.7.48) | protein | 236 | 10% helix, 32% strand | P03303 |
| 4 | Genome polyprotein (EC 3.4.22.29, 3.6.1.15, 3.4.22.28, 2.7.7.48) | protein | 40 | 10% helix, 3% strand | P03303 |
| C | Octanucleotide | rna | 8 | — | — |
Pockets
11 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 128 | 0.79 | 0.97 | 22 | empty |
| 2 | 70 | 0.52 | 0.86 | 17 | empty |
| 3 | 168 | 0.50 | 0.78 | 31 | empty |
| 4 | 150 | 0.44 | 0.75 | 36 | empty |
| 5 | 123 | 0.44 | 0.77 | 22 | empty |
Interfaces
8 interfaces between chains.
- 1–3 · 4097 Ų buried · 66 hydrogen bonds · protein-protein
- 1–2 · 2077 Ų buried · 31 hydrogen bonds · protein-protein
- 2–3 · 1688 Ų buried · 19 hydrogen bonds · protein-protein
- 1–4 · 932 Ų buried · 11 hydrogen bonds · protein-protein
- 3–4 · 798 Ų buried · 8 hydrogen bonds · protein-protein
Compared structures
- 7NUQ · Rhinovirus 14 virion-like at pH 6.2 · the same entry in another collection · chain 1 against 1, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P03303
- Elsewhere: RCSB PDB 7NUQ · PDBe 7NUQ · UniProt P03303
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