MolNFT v1 · #183562 · protein
Influenza A/CALIFORNIA/07/2009(H1N1) endonuclease in complex with orientin
7NUG · Polymerase acidic PROTEIN,POLYMERASE acidic protein: “Influenza A/CALIFORNIA/07/2009(H1N1) endonuclease in complex with orientin”. X-ray diffraction, 4 ligands (1PG, USE, MN), 1 pocket (best druggability 0.65). MolNFT v1 #183562 on…
- PDB
- 7NUG
- Type
- protein
- Length
- 180 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Polymerase acidic PROTEIN,POLYMERASE acidic protein
- EC
- 3.1.-.-
- UniProt
- C3W5X6
- Ligands
- 1PG, USE, MN, MG
- Pockets
- 1 · best druggability 0.65
Structure
x-ray diffraction · 1 distinct chain · 53% helix, 13% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Polymerase acidic PROTEIN,POLYMERASE acidic protein (EC 3.1.-.-) | protein | 180 | 53% helix, 13% strand | C3W5X6 |
Ligands and binding sites
- 1PG · 2-(2-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethanol · ligand · chains A
- USE · Orientin · ligand · chains A
- MN · Manganese (II) ion · metal · 2 copies · chains A
- MG · Magnesium ion · metal · chains A
- PEG · Di(hydroxyethyl)ether · additive · 3 copies · chains A
- EDO · 1,2-ethanediol · additive · 3 copies · chains A
- PG4 · Tetraethylene glycol · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 519 | 0.65 | 0.77 | 48 | MN, MG, PEG, PG4, USE |
Compared structures
- 7NUG · Influenza A/California/07/2009(H1N1) endonuclease in complex with orientin · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt C3W5X6
- Elsewhere: RCSB PDB 7NUG · PDBe 7NUG · UniProt C3W5X6
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