MolNFT v1 · #183544 · protein

VIP3BC1 tetramer in processed, activated state

7NTX · Vegetative insecticidal protein: “VIP3BC1 tetramer in processed, activated state”. Electron microscopy, 20 pockets (best druggability 0.83). MolNFT v1 #183544 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 7NTX
Type: protein
Length: 2,592 residues
Chains: 4
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Vegetative insecticidal protein
UniProt: A0A290WPI2
Pockets: 20 · best druggability 0.83

Structure

electron microscopy · 1 distinct chain · 25% helix, 30% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, D	Vegetative insecticidal protein	protein	648	25% helix, 30% strand	A0A290WPI2

Pockets

20 pockets found on a 1 Å grid, 8 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	709	0.83	0.87	69	empty
2	142	0.82	0.98	36	empty
3	146	0.82	0.98	37	empty
4	104	0.71	0.93	22	empty
5	108	0.70	0.92	25	empty

Interfaces

6 interfaces between chains.

C–D · 2009 Å² buried · 25 hydrogen bonds · protein-protein
A–B · 2000 Å² buried · 25 hydrogen bonds · protein-protein
B–C · 1993 Å² buried · 25 hydrogen bonds · protein-protein
A–D · 1991 Å² buried · 25 hydrogen bonds · protein-protein
A–C · 94 Å² buried · 0 hydrogen bonds · protein-protein

Compared structures

7NTX · Vip3Bc1 tetramer in processed, activated state · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt A0A290WPI2
Elsewhere: RCSB PDB 7NTX · PDBe 7NTX · UniProt A0A290WPI2

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.