MolNFT v1 · #183522 · protein

Influenza virus H3N2 nucleoprotein - R416A mutant

7NT8 · Glutathione S-transferase class-mu 26 kda isozyme…: “Influenza virus H3N2 nucleoprotein - R416A mutant”. X-ray diffraction, 9 pockets (best druggability 0.74). MolNFT v1 #183522 on GenesisL1: 3D structure, binding sites and pockets…

PDB: 7NT8
Type: protein
Length: 858 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Glutathione S-transferase class-mu 26 kda isozyme, nucleoprotein
EC: 2.5.1.18
UniProt: Q1AR08
Pockets: 9 · best druggability 0.74

Structure

x-ray diffraction · 2 distinct chains · 49% helix, 9% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Glutathione S-transferase class-mu 26 kda isozyme, nucleoprotein (EC 2.5.1.18)	protein	439	49% helix, 8% strand	Q1AR08
B	Glutathione S-transferase class-mu 26 kda isozyme, nucleoprotein (EC 2.5.1.18)	protein	419	49% helix, 9% strand	Q1AR08

Pockets

9 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1000	0.74	0.77	101	empty
2	421	0.72	0.83	58	empty
3	497	0.69	0.79	49	empty
4	410	0.64	0.78	44	empty
5	361	0.56	0.75	43	empty

Interfaces

1 interface between chains.

A–B · 691 Å² buried · 12 hydrogen bonds · protein-protein

Compared structures

7NT8 · Influenza virus H3N2 nucleoprotein - R416A mutant · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q1AR08
Elsewhere: RCSB PDB 7NT8 · PDBe 7NT8 · UniProt Q1AR08

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