MolNFT v1 · #183512 · protein
COLICINE9 partial translocation complex
7NST · Outer membrane protein F: “COLICINE9 partial translocation complex”. Electron microscopy, 19 pockets (best druggability 0.81). MolNFT v1 #183512 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7NST
- Type
- protein
- Length
- 1,703 residues
- Chains
- 5
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Outer membrane protein F; Colicin-E9; Tol-pal system protein tolb
- EC
- 3.1.-.-
- UniProt
- P02931, P09883, A0A6D2XIU5
- Pockets
- 19 · best druggability 0.81
Structure
electron microscopy · 3 distinct chains · 10% helix, 44% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C | Outer membrane protein F | protein | 340 | 5% helix, 58% strand | P02931 |
| D | Colicin-E9 (EC 3.1.-.-) | protein | 289 | 16% helix, 28% strand | P09883 |
| E | Tol-pal system protein tolb | protein | 394 | 11% helix, 44% strand | A0A6D2XIU5 |
Pockets
19 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 645 | 0.81 | 0.86 | 61 | empty |
| 2 | 1178 | 0.73 | 0.76 | 116 | empty |
| 3 | 533 | 0.72 | 0.81 | 48 | empty |
| 4 | 1022 | 0.72 | 0.76 | 69 | empty |
| 5 | 765 | 0.71 | 0.77 | 51 | empty |
Interfaces
8 interfaces between chains.
- B–C · 1500 Ų buried · 20 hydrogen bonds · protein-protein
- A–B · 1480 Ų buried · 16 hydrogen bonds · protein-protein
- A–C · 1468 Ų buried · 16 hydrogen bonds · protein-protein
- C–D · 1304 Ų buried · 16 hydrogen bonds · protein-protein
- A–D · 1272 Ų buried · 29 hydrogen bonds · protein-protein
Compared structures
- 7NST · ColicinE9 partial translocation complex · the same entry in another collection · chain B against B, TM-score 1.00
- P02931 · AlphaFold monomer V2.0 prediction for outer membrane porin F (P02931) · a predicted model of the same protein · chain A against A, TM-score 1.00
- P09883 · AlphaFold monomer V2.0 prediction for colicin-E9 (P09883) · a predicted model of the same protein · chain D against A, TM-score 0.77
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P02931
- Every structure of UniProt P09883
- Every structure of UniProt A0A6D2XIU5
- Elsewhere: RCSB PDB 7NST · PDBe 7NST · UniProt P02931 · UniProt P09883 · UniProt A0A6D2XIU5
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