MolNFT v1 · #183509 · protein

Al amyloid fibril from a lambda 1 light chain

7NSL · Amyloid LAMBDA1 light chain: “Al amyloid fibril from a lambda 1 light chain”. Electron microscopy, 3 pockets (best druggability 0.69). MolNFT v1 #183509 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 7NSL
Type: protein
Length: 595 residues
Chains: 7
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Amyloid LAMBDA1 light chain
Pockets: 3 · best druggability 0.69

Structure

electron microscopy · 1 distinct chain · 0% helix, 41% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
D, E, F, C, B, A, G	Amyloid LAMBDA1 light chain	protein	85	0% helix, 41% strand	—

Pockets

3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	128	0.69	0.91	56	empty
2	54	0.60	0.92	33	empty
3	150	0.47	0.77	32	empty

Interfaces

11 interfaces between chains.

E–F · 3401 Å² buried · 98 hydrogen bonds · protein-protein
F–G · 3400 Å² buried · 98 hydrogen bonds · protein-protein
D–E · 3398 Å² buried · 98 hydrogen bonds · protein-protein
D–C · 3397 Å² buried · 98 hydrogen bonds · protein-protein
B–A · 3395 Å² buried · 98 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 7 disulfide (disulfide).

Compared structures

7NSL · AL amyloid fibril from a lambda 1 light chain · the same entry in another collection · chain D against D, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 7NSL · PDBe 7NSL

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