MolNFT v1 · #183396 · protein
Structure of the mature rsv ca lattice: group III, hexamer-hexamer interface, class 3'3
7NOC · Capsid protein P27, alternate cleaved 1: “Structure of the mature rsv ca lattice: group III, hexamer-hexamer interface, class 3'3”. Electron microscopy, 13 pockets (best druggability 0.59). MolNFT v1 #183396 on GenesisL1: 3D…
- PDB
- 7NOC
- Type
- protein
- Length
- 1,302 residues
- Chains
- 10
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Capsid protein P27, alternate cleaved 1
- UniProt
- P03322
- Pockets
- 13 · best druggability 0.59
Structure
electron microscopy · 3 distinct chains · 66% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, D, G, I | Capsid protein P27, alternate cleaved 1 | protein | 78 | 63% helix, 0% strand | P03322 |
| B, E | Capsid protein P27, alternate cleaved 1 | protein | 217 | 66% helix, 0% strand | P03322 |
| C, F, H, J | Capsid protein P27, alternate cleaved 1 | protein | 139 | 68% helix, 0% strand | P03322 |
Pockets
13 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 652 | 0.59 | 0.73 | 106 | empty |
| 2 | 390 | 0.52 | 0.73 | 65 | empty |
| 3 | 357 | 0.50 | 0.73 | 69 | empty |
| 4 | 320 | 0.48 | 0.72 | 69 | empty |
| 5 | 236 | 0.44 | 0.72 | 46 | empty |
Interfaces
12 interfaces between chains.
- E–F · 103 Ų buried · 0 hydrogen bonds · protein-protein
- B–C · 93 Ų buried · 0 hydrogen bonds · protein-protein
- B–G · 87 Ų buried · 0 hydrogen bonds · protein-protein
- A–E · 80 Ų buried · 0 hydrogen bonds · protein-protein
- B–D · 79 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 7NOC · Structure of the mature RSV CA lattice: Group III, hexamer-hexamer interface, class 3'3 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P03322
- Elsewhere: RCSB PDB 7NOC · PDBe 7NOC · UniProt P03322
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