MolNFT v1 · #183315 · protein

S. cerevisiae TY1 P22 restriction factor, gag ca-ctd, AUG1 variant

7NLH · TY1 gag P22: “S. cerevisiae TY1 P22 restriction factor, gag ca-ctd, AUG1 variant”. X-ray diffraction, 2 pockets (best druggability 0.39). MolNFT v1 #183315 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 7NLH
Type: protein
Length: 271 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: TY1 gag P22
UniProt: P08405
Pockets: 2 · best druggability 0.39

Structure

x-ray diffraction · 2 distinct chains · 62% helix, 2% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, C	TY1 gag P22	protein	90	61% helix, 2% strand	P08405
B	TY1 gag P22	protein	91	63% helix, 2% strand	P08405

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	53	0.39	0.81	13	empty
2	55	0.37	0.80	12	empty

Interfaces

2 interfaces between chains.

A–B · 844 Å² buried · 11 hydrogen bonds · protein-protein
A–C · 729 Å² buried · 7 hydrogen bonds · protein-protein

Compared structures

7NLH · S. cerevisiae Ty1 p22 restriction factor, Gag CA-CTD, AUG1 variant · the same entry in another collection · chain A against A, TM-score 1.00
P08405 · AlphaFold monomer V2.0 prediction for transposon TYH3 gag polyprotein (P08405) · a predicted model of the same protein · chain B against A, TM-score 0.96

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P08405
Elsewhere: RCSB PDB 7NLH · PDBe 7NLH · UniProt P08405

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