MolNFT v1 · #183314 · protein

S. cerevisiae TY1 P22 restriction factor, gag ca-ctd, AUG2 variant A273V mutant

7NLG · TY1 gag P22: “S. cerevisiae TY1 P22 restriction factor, gag ca-ctd, AUG2 variant A273V mutant”. X-ray diffraction, 2 pockets (best druggability 0.42). MolNFT v1 #183314 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 7NLG
Type: protein
Length: 270 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: TY1 gag P22
UniProt: P08405
Pockets: 2 · best druggability 0.42

Structure

x-ray diffraction · 1 distinct chain · 62% helix, 3% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C	TY1 gag P22	protein	90	62% helix, 3% strand	P08405

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	66	0.42	0.81	13	empty
2	70	0.41	0.80	13	empty

Interfaces

2 interfaces between chains.

A–B · 811 Å² buried · 6 hydrogen bonds · protein-protein
A–C · 773 Å² buried · 6 hydrogen bonds · protein-protein

Compared structures

7NLG · S. cerevisiae Ty1 p22 restriction factor, Gag CA-CTD, AUG2 variant A273V mutant · the same entry in another collection · chain B against B, TM-score 1.00
P08405 · AlphaFold monomer V2.0 prediction for transposon TYH3 gag polyprotein (P08405) · a predicted model of the same protein · chain A against A, TM-score 0.95

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P08405
Elsewhere: RCSB PDB 7NLG · PDBe 7NLG · UniProt P08405

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