MolNFT v1 · #183177 · protein + RNA
1918 H1N1 viral influenza polymerase heterotrimer - endonuclease and priming loop ordered (CLASS2A)
7NHA · Polymerase acidic protein: “1918 H1N1 viral influenza polymerase heterotrimer - endonuclease and priming loop ordered (CLASS2A)”. Electron microscopy, 20 pockets (best druggability 0.82). MolNFT v1 #183177 on GenesisL1: 3D…
- PDB
- 7NHA
- Type
- protein + RNA
- Length
- 1,723 residues
- Chains
- 5
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Polymerase acidic protein; RNA-directed RNA polymerase catalytic subunit; Polymerase…
- EC
- 3.1.-.-, 2.7.7.48
- UniProt
- Q3HM39, Q3HM40, Q3HM41
- Pockets
- 20 · best druggability 0.82
Structure
electron microscopy · 5 distinct chains · 44% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Polymerase acidic protein (EC 3.1.-.-) | protein | 716 | 42% helix, 16% strand | Q3HM39 |
| B | RNA-directed RNA polymerase catalytic subunit (EC 2.7.7.48) | protein | 735 | 47% helix, 15% strand | Q3HM40 |
| C | Polymerase basic protein 2,IMMUNOGLOBULIN G-binding protein a | protein | 249 | 43% helix, 17% strand | Q3HM41 |
| E | RNA (5'-R(P*GP*GP*CP*CP*UP*GP*CP*U)-3') | rna | 8 | — | — |
| D | RNA (5'-R(P*AP*GP*UP*AP*GP*AP*AP*AP*CP*AP*AP*GP*GP*CP*C)- 3') | rna | 15 | — | — |
Pockets
20 pockets found on a 1 Å grid, 11 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1047 | 0.82 | 0.83 | 84 | empty |
| 2 | 615 | 0.81 | 0.86 | 60 | empty |
| 3 | 495 | 0.80 | 0.88 | 65 | empty |
| 4 | 975 | 0.80 | 0.81 | 116 | empty |
| 5 | 161 | 0.73 | 0.91 | 32 | empty |
Interfaces
9 interfaces between chains.
- A–B · 8966 Ų buried · 106 hydrogen bonds · protein-protein
- B–C · 6778 Ų buried · 53 hydrogen bonds · protein-protein
- A–D · 1401 Ų buried · 20 hydrogen bonds · protein-nucleic
- A–C · 1318 Ų buried · 10 hydrogen bonds · protein-protein
- B–D · 626 Ų buried · 6 hydrogen bonds · protein-nucleic
Compared structures
- 7NHA · 1918 H1N1 Viral influenza polymerase heterotrimer - Endonuclease and priming loop ordered… · the same entry in another collection · chain B against B, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q3HM39
- Every structure of UniProt Q3HM40
- Every structure of UniProt Q3HM41
- Elsewhere: RCSB PDB 7NHA · PDBe 7NHA · UniProt Q3HM39 · UniProt Q3HM40 · UniProt Q3HM41
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