MolNFT v1 · #183173 · protein
Co-crystal structure of AKT1 in complex with covalent-allosteric AKT inhibitor 3
7NH4: “Co-crystal structure of AKT1 in complex with covalent-allosteric AKT inhibitor 3”. X-ray diffraction, 1 ligand (UCE). MolNFT v1 #183173 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7NH4
- Type
- protein
- Length
- 383 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- P31749
- Ligands
- UCE
Structure
x-ray diffraction · 1 distinct chain.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 383 | — | P31749 |
Ligands and binding sites
- UCE · ~{N}-[3-[1-[[4-[5-(hydroxymethyl)-3-phenyl-pyridin-2-yl]phenyl]methyl]piperidin-4-yl]-2-oxidanylidene-1~{H}-benzimidazol-5-yl]propanamide · ligand · chains A
- ACT · Acetate ion · additive · 2 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 7NH4 · Co-Crystal Structure of Akt1 in Complex with Covalent-Allosteric Akt Inhibitor 3 · the same entry in another collection · chain A against A, TM-score 1.00
- P31749 · AlphaFold monomer V2.0 prediction for rac-alpha SERINE/THREONINE- protein kinase (P31749) · a predicted model of the same protein · chain A against A, TM-score 0.71
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P31749
- Elsewhere: RCSB PDB 7NH4 · PDBe 7NH4 · UniProt P31749
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