MolNFT v1 · #183172 · protein

Nematocida HUWE1 in open conformation

7NH3 · E3 ubiquitin-protein ligase HUWE1: “Nematocida HUWE1 in open conformation”. Electron microscopy, 20 pockets (best druggability 0.83). MolNFT v1 #183172 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 7NH3
Type: protein
Length: 2,138 residues
Chains: 1
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: E3 ubiquitin-protein ligase HUWE1
UniProt: A0A177ELV2
Pockets: 20 · best druggability 0.83

Structure

electron microscopy · 1 distinct chain · 65% helix, 2% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	E3 ubiquitin-protein ligase HUWE1	protein	2138	65% helix, 2% strand	A0A177ELV2

Pockets

20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	451	0.83	0.90	73	empty
2	244	0.81	0.93	43	empty
3	146	0.80	0.96	30	empty
4	215	0.77	0.91	33	empty
5	101	0.77	0.96	24	empty

Compared structures

7NH3 · Nematocida Huwe1 in open conformation. · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt A0A177ELV2
Elsewhere: RCSB PDB 7NH3 · PDBe 7NH3 · UniProt A0A177ELV2

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