MolNFT v1 · #183148 · protein
Structure of wild-type human potassium chloride transporter KCC3 in nacl (LMNG/CHS)
7NGB · Isoform 2 of solute carrier family 12 member 6: “Structure of wild-type human potassium chloride transporter KCC3 in nacl (LMNG/CHS)”. Electron microscopy, 2 ligands (NAG, BMA), 20 pockets (best druggability 0.76). MolNFT v1 #183148…
- PDB
- 7NGB
- Type
- protein
- Length
- 1,718 residues
- Chains
- 2
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Isoform 2 of solute carrier family 12 member 6
- UniProt
- Q9UHW9
- Ligands
- NAG, BMA
- Pockets
- 20 · best druggability 0.76
Structure
electron microscopy · 1 distinct chain · 55% helix, 10% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Isoform 2 of solute carrier family 12 member 6 | protein | 859 | 55% helix, 10% strand | Q9UHW9 |
Ligands and binding sites
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 6 copies · chains A, B
- BMA · beta-D-mannopyranose · sugar · 2 copies
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 11 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 519 | 0.76 | 0.83 | 58 | empty |
| 2 | 485 | 0.75 | 0.84 | 54 | empty |
| 3 | 661 | 0.75 | 0.81 | 74 | empty |
| 4 | 600 | 0.73 | 0.80 | 47 | empty |
| 5 | 600 | 0.73 | 0.80 | 49 | empty |
Interfaces
1 interface between chains.
- A–B · 3394 Ų buried · 24 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 6 disulfide, 4 glycan (disulfide, N-glycosylation).
Compared structures
- 7NGB · Structure of Wild-Type Human Potassium Chloride Transporter KCC3 in NaCl (LMNG/CHS) · the same entry in another collection · chain A against A, TM-score 1.00
- Q9UHW9 · AlphaFold monomer V2.0 prediction for solute carrier family 12 member 6 (Q9UHW9) · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9UHW9
- Elsewhere: RCSB PDB 7NGB · PDBe 7NGB · UniProt Q9UHW9
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