MolNFT v1 · #183081 · protein

Crystal structure of branched-chain amino acid aminotransferase from thermobaculum terrenum (M4 mutant)

7NEB · Branched-chain-amino-acid aminotransferase: “Crystal structure of branched-chain amino acid aminotransferase from thermobaculum terrenum (M4 mutant)”. X-ray diffraction, 2 ligands (PLP, NA), 3 pockets (best druggability 0.55).…

PDB: 7NEB
Type: protein
Length: 302 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Branched-chain-amino-acid aminotransferase
EC: 2.6.1.42
UniProt: D1CCW1
Ligands: PLP, NA
Pockets: 3 · best druggability 0.55

Structure

x-ray diffraction · 1 distinct chain · 30% helix, 31% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Branched-chain-amino-acid aminotransferase (EC 2.6.1.42)	protein	302	30% helix, 31% strand	D1CCW1

Ligands and binding sites

PLP · Pyridoxal-5'-phosphate · ligand · chains A
NA · Sodium ion · metal · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	207	0.55	0.78	44	PLP
2	159	0.47	0.75	19	empty
3	56	0.26	0.73	13	empty

Modifications

Observed in the structure: 1 cofactor (pyridoxal phosphate Schiff base).

Compared structures

7NEB · Crystal structure of branched-chain amino acid aminotransferase from Thermobaculum… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt D1CCW1
Elsewhere: RCSB PDB 7NEB · PDBe 7NEB · UniProt D1CCW1

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