MolNFT v1 · #182929 · protein
Oxidized phers G318W from salmonella enterica serovar typhimurium
7N8Y · Phenylalanine--tRNA ligase alpha subunit: “Oxidized phers G318W from salmonella enterica serovar typhimurium”. Electron microscopy, 20 pockets (best druggability 0.77). MolNFT v1 #182929 on GenesisL1: 3D structure, binding sites and…
- PDB
- 7N8Y
- Type
- protein
- Length
- 2,074 residues
- Chains
- 4
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Phenylalanine--tRNA ligase alpha subunit; Phenylalanine--tRNA ligase beta subunit
- EC
- 6.1.1.20
- UniProt
- A0A0F7J874, A0A0D6GBX6
- Pockets
- 20 · best druggability 0.77
Structure
electron microscopy · 2 distinct chains · 20% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C | Phenylalanine--tRNA ligase alpha subunit (EC 6.1.1.20) | protein | 242 | 25% helix, 19% strand | A0A0F7J874 |
| B, D | Phenylalanine--tRNA ligase beta subunit (EC 6.1.1.20) | protein | 795 | 18% helix, 18% strand | A0A0D6GBX6 |
Pockets
20 pockets found on a 1 Å grid, 19 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 333 | 0.77 | 0.88 | 32 | empty |
| 2 | 840 | 0.73 | 0.78 | 73 | empty |
| 3 | 791 | 0.73 | 0.78 | 69 | empty |
| 4 | 449 | 0.72 | 0.82 | 41 | empty |
| 5 | 404 | 0.72 | 0.83 | 44 | empty |
Interfaces
6 interfaces between chains.
- C–D · 3612 Ų buried · 27 hydrogen bonds · protein-protein
- A–B · 3585 Ų buried · 30 hydrogen bonds · protein-protein
- B–C · 2087 Ų buried · 18 hydrogen bonds · protein-protein
- A–D · 2065 Ų buried · 18 hydrogen bonds · protein-protein
- B–D · 1334 Ų buried · 18 hydrogen bonds · protein-protein
Compared structures
- 7N8Y · Oxidized PheRS G318W from Salmonella enterica serovar Typhimurium · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A0F7J874
- Every structure of UniProt A0A0D6GBX6
- Elsewhere: RCSB PDB 7N8Y · PDBe 7N8Y · UniProt A0A0F7J874 · UniProt A0A0D6GBX6
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