Crystal structure of the N-formyltransferase HCAN_0200 from helicobacter canadensis in complex with folinic acid and dtdp-3- aminoquinovose

Structure

x-ray diffraction · 1 distinct chain · 27% helix, 27% strand (DSSP).

Ligands and binding sites

• FON · N-{[4-({[(6R)-2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)phenyl]carbonyl}-L-glutamic acid · ligand · 2 copies · chains A, B
• T3Q · [(3R,4S,5S,6R)-4-amino-3,5-dihydroxy-6-methyloxan-2-yl][hydroxy-[[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy]phosphoryl] hydrogen phosphate · ligand · 2 copies · chains A, B
• K · Potassium ion · metal · 2 copies · chains A, B
• EDO · 1,2-ethanediol · additive · 3 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

5 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Interfaces

1 interface between chains.

• A–B · 1256 Ų buried · 18 hydrogen bonds · protein-protein

Compared structures

• 7N7C · crystal structure of the N-formyltransferase HCAN_0200 from helicobacter canadensis in… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt C5ZW02
• Elsewhere: RCSB PDB 7N7C · PDBe 7N7C · UniProt C5ZW02