MolNFT v1 · #182814 · protein
Structure of mechanosensitive ion channel FLYCATCHER1 in gdn
7N5E: “Structure of mechanosensitive ion channel FLYCATCHER1 in gdn”. Electron microscopy, 1 ligand (PLM), 20 pockets (best druggability 0.76). MolNFT v1 #182814 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7N5E
- Type
- protein
- Length
- 2,176 residues
- Chains
- 7
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Mechanosensitive ion channel FLYCATCHER1
- Ligands
- PLM
- Pockets
- 20 · best druggability 0.76
Structure
electron microscopy · 2 distinct chains · 56% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Mechanosensitive ion channel FLYCATCHER1 | protein | 316 | 57% helix, 20% strand | — |
| B, C, D, E, F, G | Mechanosensitive ion channel FLYCATCHER1 | protein | 310 | 55% helix, 19% strand | — |
Ligands and binding sites
- PLM · Palmitic acid · ligand · 7 copies · chains A, B, C, D, E, F, G
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 19 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1049 | 0.76 | 0.78 | 102 | PLM |
| 2 | 729 | 0.69 | 0.76 | 72 | empty |
| 3 | 719 | 0.65 | 0.73 | 73 | empty |
| 4 | 433 | 0.61 | 0.76 | 57 | empty |
| 5 | 368 | 0.60 | 0.75 | 21 | empty |
Interfaces
14 interfaces between chains.
- A–B · 2612 Ų buried · 21 hydrogen bonds · protein-protein
- F–G · 2340 Ų buried · 19 hydrogen bonds · protein-protein
- C–D · 2315 Ų buried · 21 hydrogen bonds · protein-protein
- D–E · 2313 Ų buried · 23 hydrogen bonds · protein-protein
- B–C · 2304 Ų buried · 20 hydrogen bonds · protein-protein
Compared structures
- 7N5E · Structure of Mechanosensitive Ion Channel Flycatcher1 in GDN · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 7N5E · PDBe 7N5E
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