MolNFT v1 · #182769 · protein + RNA
Cryo-EM structure of the CAS12K-sgrna complex
7N3O: “Cryo-EM structure of the CAS12K-sgrna complex”. Electron microscopy, 17 pockets (best druggability 0.79). MolNFT v1 #182769 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7N3O
- Type
- protein + RNA
- Length
- 676 residues
- Chains
- 2
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- CAS12K; Single guide RNA
- Pockets
- 17 · best druggability 0.79
Structure
electron microscopy · 2 distinct chains · 53% helix, 14% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | CAS12K | protein | 454 | 53% helix, 14% strand | — |
| B | Single guide RNA | rna | 222 | — | — |
Pockets
17 pockets found on a 1 Å grid, 9 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 939 | 0.79 | 0.82 | 62 | empty |
| 2 | 793 | 0.77 | 0.81 | 57 | empty |
| 3 | 1032 | 0.75 | 0.78 | 55 | empty |
| 4 | 622 | 0.73 | 0.81 | 40 | empty |
| 5 | 62 | 0.68 | 0.95 | 17 | empty |
Interfaces
1 interface between chains.
- A–B · 3471 Ų buried · 79 hydrogen bonds · protein-nucleic
Compared structures
- 7N3O · Cryo-EM structure of the Cas12k-sgRNA complex · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 7N3O · PDBe 7N3O
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