MolNFT v1 · #182764 · protein

Crystal structure of an anti-SARS-cov-2 human neutralizing antibody Fab fragment C099

7N3H · C099 Fab heavy chain: “Crystal structure of an anti-SARS-cov-2 human neutralizing antibody Fab fragment C099”. X-ray diffraction, 5 pockets (best druggability 0.53). MolNFT v1 #182764 on GenesisL1: 3D structure, binding sites and…

PDB: 7N3H
Type: protein
Length: 427 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: C099 Fab heavy chain; C099 Fab light chain
Pockets: 5 · best druggability 0.53

Structure

x-ray diffraction · 2 distinct chains · 8% helix, 51% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
H	C099 Fab heavy chain	protein	214	8% helix, 52% strand	—
L	C099 Fab light chain	protein	213	8% helix, 51% strand	—

Pockets

5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	328	0.53	0.74	45	empty
2	51	0.53	0.89	18	empty
3	122	0.36	0.73	17	empty
4	100	0.33	0.73	20	empty
5	63	0.29	0.73	19	empty

Interfaces

1 interface between chains.

H–L · 1812 Å² buried · 15 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 disulfide (disulfide).

Compared structures

7N3H · Crystal structure of an anti-SARS-CoV-2 human neutralizing antibody Fab fragment C099 · the same entry in another collection · chain H against H, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 7N3H · PDBe 7N3H

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