MolNFT v1 · #182763 · protein

Crystal structure of an anti-SARS-cov-2 human neutralizing antibody Fab fragment C098

7N3G · C098 Fab heavy chain: “Crystal structure of an anti-SARS-cov-2 human neutralizing antibody Fab fragment C098”. X-ray diffraction, 5 pockets (best druggability 0.59). MolNFT v1 #182763 on GenesisL1: 3D structure, binding sites and…

PDB: 7N3G
Type: protein
Length: 431 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: C098 Fab heavy chain; C098 Fab light chain
Pockets: 5 · best druggability 0.59

Structure

x-ray diffraction · 2 distinct chains · 8% helix, 54% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
H	C098 Fab heavy chain	protein	217	8% helix, 54% strand	—
L	C098 Fab light chain	protein	214	7% helix, 53% strand	—

Pockets

5 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	461	0.59	0.74	51	empty
2	57	0.56	0.90	21	empty
3	64	0.55	0.88	18	empty
4	71	0.39	0.79	22	empty
5	88	0.30	0.72	19	empty

Interfaces

1 interface between chains.

H–L · 1758 Å² buried · 14 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 disulfide (disulfide).

Compared structures

7N3G · Crystal structure of an anti-SARS-CoV-2 human neutralizing antibody Fab fragment C098 · the same entry in another collection · chain H against H, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 7N3G · PDBe 7N3G

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