MolNFT v1 · #182680 · protein
Inactivated state of 2-apb-bound wildtype rat TRPV2 in nanodiscs
7N0M · Transient receptor potential cation channel subfamily V…: “Inactivated state of 2-apb-bound wildtype rat TRPV2 in nanodiscs”. Electron microscopy, 1 ligand (FZ4), 20 pockets (best druggability 0.86). MolNFT v1 #182680 on GenesisL1…
- PDB
- 7N0M
- Type
- protein
- Length
- 2,476 residues
- Chains
- 4
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Transient receptor potential cation channel subfamily V member 2
- UniProt
- Q9WUD2
- Ligands
- FZ4
- Pockets
- 20 · best druggability 0.86
Structure
electron microscopy · 1 distinct chain · 52% helix, 5% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D | Transient receptor potential cation channel subfamily V member 2 | protein | 619 | 52% helix, 5% strand | Q9WUD2 |
Ligands and binding sites
- FZ4 · 2-aminoethyl diphenylborinate · ligand · 4 copies · chains A, D, B, C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1153 | 0.86 | 0.87 | 81 | empty |
| 2 | 393 | 0.82 | 0.90 | 37 | empty |
| 3 | 392 | 0.82 | 0.90 | 37 | empty |
| 4 | 384 | 0.82 | 0.90 | 34 | empty |
| 5 | 390 | 0.81 | 0.90 | 34 | empty |
Interfaces
6 interfaces between chains.
- A–B · 2675 Ų buried · 12 hydrogen bonds · protein-protein
- A–D · 2639 Ų buried · 10 hydrogen bonds · protein-protein
- C–D · 2627 Ų buried · 10 hydrogen bonds · protein-protein
- B–C · 2626 Ų buried · 10 hydrogen bonds · protein-protein
- A–C · 19 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 7N0M · Inactivated state of 2-APB-bound wildtype rat TRPV2 in nanodiscs · the same entry in another collection · chain A against A, TM-score 1.00
- Q9WUD2 · AlphaFold monomer V2.0 prediction for transient receptor potential cation channel… · a predicted model of the same protein · chain A against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9WUD2
- Elsewhere: RCSB PDB 7N0M · PDBe 7N0M · UniProt Q9WUD2
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