MolNFT v1 · #182655 · protein
Structure of yeast pseudouridine synthase 7 (PUS7)
7MZV · Multisubstrate pseudouridine synthase 7: “Structure of yeast pseudouridine synthase 7 (PUS7)”. X-ray diffraction, 1 ligand (SO4), 5 pockets (best druggability 0.50). MolNFT v1 #182655 on GenesisL1: 3D structure, binding sites and…
- PDB
- 7MZV
- Type
- protein
- Length
- 583 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Multisubstrate pseudouridine synthase 7
- EC
- 5.4.99.-, 5.4.99.27
- UniProt
- Q08647
- Ligands
- SO4
- Pockets
- 5 · best druggability 0.50
Structure
x-ray diffraction · 1 distinct chain · 36% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Multisubstrate pseudouridine synthase 7 (EC 5.4.99.-, 5.4.99.27) | protein | 583 | 36% helix, 16% strand | Q08647 |
Ligands and binding sites
- SO4 · Sulfate ion · ion · 3 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 214 | 0.50 | 0.76 | 30 | empty |
| 2 | 130 | 0.40 | 0.74 | 17 | empty |
| 3 | 82 | 0.34 | 0.75 | 16 | empty |
| 4 | 59 | 0.30 | 0.75 | 16 | empty |
| 5 | 69 | 0.29 | 0.73 | 16 | empty |
Modifications
Observed in the structure: 15 modified (engineered).
Compared structures
- 7MZV · Structure of yeast pseudouridine synthase 7 (PUS7) · the same entry in another collection · chain A against A, TM-score 1.00
- Q08647 · AlphaFold monomer V2.0 prediction for multisubstrate pseudouridine synthase 7 (Q08647) · a predicted model of the same protein · chain A against A, TM-score 0.78
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q08647
- Elsewhere: RCSB PDB 7MZV · PDBe 7MZV · UniProt Q08647
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