MolNFT v1 · #182622 · protein
Plasmodium falciparum HAD5/PMM
7MYV · Phosphomannomutase: “Plasmodium falciparum HAD5/PMM”. X-ray diffraction, 1 ligand (MG), 3 pockets (best druggability 0.62). MolNFT v1 #182622 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7MYV
- Type
- protein
- Length
- 477 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Phosphomannomutase
- EC
- 5.4.2.8
- UniProt
- Q8IJM5
- Ligands
- MG
- Pockets
- 3 · best druggability 0.62
Structure
x-ray diffraction · 2 distinct chains · 40% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Phosphomannomutase (EC 5.4.2.8) | protein | 238 | 41% helix, 20% strand | Q8IJM5 |
| B | Phosphomannomutase (EC 5.4.2.8) | protein | 239 | 38% helix, 23% strand | Q8IJM5 |
Ligands and binding sites
- MG · Magnesium ion · metal · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 461 | 0.62 | 0.76 | 38 | MG |
| 2 | 361 | 0.56 | 0.75 | 34 | MG |
| 3 | 102 | 0.35 | 0.74 | 16 | empty |
Interfaces
1 interface between chains.
- A–B · 1098 Ų buried · 16 hydrogen bonds · protein-protein
Compared structures
- 7MYV · Plasmodium falciparum HAD5/PMM · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8IJM5
- Elsewhere: RCSB PDB 7MYV · PDBe 7MYV · UniProt Q8IJM5
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