MolNFT v1 · #182541 · protein
Single particle cryo-EM structure of the chaetomium thermophilum NUP188-NIC96 complex (NUP188 residues 1-1858; NIC96 residues 240-301)
7MVY · Nucleoporin NUP188: “Single particle cryo-EM structure of the chaetomium thermophilum NUP188-NIC96 complex (NUP188 residues…”. Electron microscopy, 20 pockets (best druggability 0.83). MolNFT v1 #182541 on GenesisL1: 3D structure…
- PDB
- 7MVY
- Type
- protein
- Length
- 1,694 residues
- Chains
- 2
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Nucleoporin NUP188; Nucleoporin NIC96
- UniProt
- G0SFH5, G0S024
- Pockets
- 20 · best druggability 0.83
Structure
electron microscopy · 2 distinct chains · 66% helix, 1% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Nucleoporin NUP188 | protein | 1641 | 66% helix, 1% strand | G0SFH5 |
| B | Nucleoporin NIC96 | protein | 53 | 81% helix, 0% strand | G0S024 |
Pockets
20 pockets found on a 1 Å grid, 12 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1025 | 0.83 | 0.84 | 97 | empty |
| 2 | 271 | 0.81 | 0.92 | 41 | empty |
| 3 | 582 | 0.80 | 0.86 | 70 | empty |
| 4 | 831 | 0.76 | 0.80 | 81 | empty |
| 5 | 289 | 0.76 | 0.88 | 42 | empty |
Interfaces
1 interface between chains.
- A–B · 1927 Ų buried · 15 hydrogen bonds · protein-protein
Compared structures
- 7MVY · Single particle cryo-EM structure of the Chaetomium thermophilum Nup188-Nic96 complex… · the same entry in another collection · chain A against A, TM-score 1.00
- G0SFH5 · AlphaFold monomer V2.0 prediction for nucleoporin NUP188 (G0SFH5) · a predicted model of the same protein · chain A against A, TM-score 0.97
- G0S024 · AlphaFold monomer V2.0 prediction for nucleoporin NIC96 (G0S024) · a predicted model of the same protein · chain B against A, TM-score 0.62
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt G0SFH5
- Every structure of UniProt G0S024
- Elsewhere: RCSB PDB 7MVY · PDBe 7MVY · UniProt G0SFH5 · UniProt G0S024
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