MolNFT v1 · #182540 · protein
Crystal structure of the chaetomium thermophilum NUP188-NIC96 complex (NUP188 residues 1-1858; NIC96 residues 240-301)
7MVX · Nucleoporin NUP188: “Crystal structure of the chaetomium thermophilum NUP188-NIC96 complex (NUP188 residues 1-1858; NIC96 residues…”. X-ray diffraction, 20 pockets (best druggability 0.84). MolNFT v1 #182540 on GenesisL1: 3D…
- PDB
- 7MVX
- Type
- protein
- Length
- 1,699 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Nucleoporin NUP188; Nucleoporin NIC96
- UniProt
- G0SFH5, G0S024
- Pockets
- 20 · best druggability 0.84
Structure
x-ray diffraction · 2 distinct chains · 67% helix, 2% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Nucleoporin NUP188 | protein | 1645 | 67% helix, 2% strand | G0SFH5 |
| B | Nucleoporin NIC96 | protein | 54 | 80% helix, 0% strand | G0S024 |
Pockets
20 pockets found on a 1 Å grid, 16 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 999 | 0.84 | 0.85 | 88 | empty |
| 2 | 911 | 0.80 | 0.82 | 78 | empty |
| 3 | 1031 | 0.77 | 0.79 | 86 | empty |
| 4 | 992 | 0.74 | 0.77 | 89 | empty |
| 5 | 76 | 0.74 | 0.97 | 22 | empty |
Interfaces
1 interface between chains.
- A–B · 1893 Ų buried · 4 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 32 modified (engineered).
Compared structures
- 7MVX · Crystal structure of the Chaetomium thermophilum Nup188-Nic96 complex (Nup188 residues… · the same entry in another collection · chain A against A, TM-score 1.00
- G0SFH5 · AlphaFold monomer V2.0 prediction for nucleoporin NUP188 (G0SFH5) · a predicted model of the same protein · chain A against A, TM-score 0.97
- G0S024 · AlphaFold monomer V2.0 prediction for nucleoporin NIC96 (G0S024) · a predicted model of the same protein · chain B against A, TM-score 0.60
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt G0SFH5
- Every structure of UniProt G0S024
- Elsewhere: RCSB PDB 7MVX · PDBe 7MVX · UniProt G0SFH5 · UniProt G0S024
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