MolNFT v1 · #182536 · protein
Crystal structure of the chaetomium thermophilum NUP192-NIC96 complex (NUP192 residues 185-1756; NIC96 residues 187-301)
7MVT · Nucleoporin NIC96: “Crystal structure of the chaetomium thermophilum NUP192-NIC96 complex (NUP192 residues 185-1756; NIC96…”. X-ray diffraction, 20 pockets (best druggability 0.72). MolNFT v1 #182536 on GenesisL1: 3D structure…
- PDB
- 7MVT
- Type
- protein
- Length
- 1,387 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Nucleoporin NIC96; Nucleoporin NUP192
- UniProt
- G0S024, G0S4T0
- Pockets
- 20 · best druggability 0.72
Structure
x-ray diffraction · 2 distinct chains · 70% helix, 1% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B | Nucleoporin NIC96 | protein | 62 | 76% helix, 0% strand | G0S024 |
| A | Nucleoporin NUP192 | protein | 1325 | 70% helix, 1% strand | G0S4T0 |
Pockets
20 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 323 | 0.72 | 0.85 | 44 | empty |
| 2 | 193 | 0.61 | 0.83 | 33 | empty |
| 3 | 411 | 0.60 | 0.76 | 39 | empty |
| 4 | 271 | 0.60 | 0.78 | 22 | empty |
| 5 | 300 | 0.55 | 0.76 | 39 | empty |
Interfaces
1 interface between chains.
- B–A · 1962 Ų buried · 10 hydrogen bonds · protein-protein
Compared structures
- 7MVT · Crystal structure of the Chaetomium thermophilum Nup192-Nic96 complex (Nup192 residues… · the same entry in another collection · chain B against B, TM-score 1.00
- G0S4T0 · AlphaFold monomer V2.0 prediction for nucleoporin NUP192 (G0S4T0) · a predicted model of the same protein · chain A against A, TM-score 0.97
- G0S024 · AlphaFold monomer V2.0 prediction for nucleoporin NIC96 (G0S024) · a predicted model of the same protein · chain B against A, TM-score 0.59
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt G0S024
- Every structure of UniProt G0S4T0
- Elsewhere: RCSB PDB 7MVT · PDBe 7MVT · UniProt G0S024 · UniProt G0S4T0
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