MolNFT v1 · #182530 · protein

Human DCTPP1 bound to triptolide

7MU5: “Human DCTPP1 bound to triptolide”. X-ray diffraction, 2 ligands (TLI, MG). MolNFT v1 #182530 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 7MU5
Type: protein
Length: 843 residues
Chains: 8
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
UniProt: Q9H773
Ligands: TLI, MG

Structure

x-ray diffraction · 7 distinct chains.

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	—	protein	110	—	Q9H773
B	—	protein	105	—	Q9H773
C, H	—	protein	104	—	Q9H773
D	—	protein	105	—	Q9H773
E	—	protein	105	—	Q9H773
F	—	protein	106	—	Q9H773
G	—	protein	104	—	Q9H773

Ligands and binding sites

TLI · triptolide · ligand · 8 copies · chains A, E, G, C, B, F, H, D
MG · Magnesium ion · metal · 6 copies · chains A, B, C, E, F, G

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

7MU5 · Human DCTPP1 bound to Triptolide · the same entry in another collection · chain H against H, TM-score 1.00
Q9H773 · AlphaFold monomer V2.0 prediction for dctp pyrophosphatase 1 (Q9H773) · a predicted model of the same protein · chain B against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9H773
Elsewhere: RCSB PDB 7MU5 · PDBe 7MU5 · UniProt Q9H773

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