MolNFT v1 · #182423 · protein + RNA
Bartonella henselae nrnc complexed with pagg. C1 reconstruction.
7MQE · Nanornase C: “Bartonella henselae nrnc complexed with pagg. C1 reconstruction.”. Electron microscopy, 20 pockets (best druggability 0.76). MolNFT v1 #182423 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7MQE
- Type
- protein + RNA
- Length
- 1,645 residues
- Chains
- 16
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Nanornase C; RNA (5'-R(P*AP*GP*G)-3')
- UniProt
- X5MEI1
- Pockets
- 20 · best druggability 0.76
Structure
electron microscopy · 4 distinct chains · 40% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C, G, M, O | Nanornase C | protein | 205 | 40% helix, 16% strand | X5MEI1 |
| E, I | Nanornase C | protein | 201 | 40% helix, 16% strand | X5MEI1 |
| K | Nanornase C | protein | 202 | 41% helix, 16% strand | X5MEI1 |
| B, D, F, H, J, L, N, P | RNA (5'-R(P*AP*GP*G)-3') | rna | 2 | — | — |
Pockets
20 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1170 | 0.76 | 0.78 | 133 | empty |
| 2 | 540 | 0.69 | 0.79 | 63 | empty |
| 3 | 507 | 0.67 | 0.78 | 60 | empty |
| 4 | 175 | 0.59 | 0.82 | 32 | empty |
| 5 | 179 | 0.57 | 0.81 | 31 | empty |
Interfaces
40 interfaces between chains.
- A–M · 1255 Ų buried · 7 hydrogen bonds · protein-protein
- E–I · 1201 Ų buried · 6 hydrogen bonds · protein-protein
- C–K · 1194 Ų buried · 7 hydrogen bonds · protein-protein
- G–O · 1192 Ų buried · 8 hydrogen bonds · protein-protein
- C–D · 437 Ų buried · 10 hydrogen bonds · protein-nucleic
Compared structures
- 7MQE · Bartonella henselae NrnC complexed with pAGG. C1 reconstruction. · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt X5MEI1
- Elsewhere: RCSB PDB 7MQE · PDBe 7MQE · UniProt X5MEI1
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